膀巨细胞癌:临床病理学分析和瘤学结果
Frederico Portugal-Gaspar1, Antonio Lopez-Beltran2, Gladell P Paner3
1Urology Department, Egas Moniz Hospital, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
Virchows Archiv : an international journal of pathology
|July 18, 2024
概括
巨细胞癌是一种罕见的膀癌亚型,具有侵略性特征,与晚期癌症有关. 这种亚型显示出与传统泌尿器官癌相比,较低的存活率趋势.
科学领域:
- 尿瘤学 尿瘤学
- 病理学 病理学 病理学
- 癌症生物学 癌症生物学
背景情况:
- 巨细胞癌是一种罕见的尿路细胞癌亚型,最近被世界卫生组织认可.
- 这种亚型的特征在于瘤内存在巨大的,奇怪的和形细胞.
- 它通常与传统的高度泌尿腺癌和各种不同的分化模式有关.
研究的目的:
- 介绍23例巨细胞泌尿腺癌的临床病理特征.
- 为了比较巨细胞尿癌与常规尿癌的临床结果.
- 分析免疫组织化学概况,包括增殖标志物和PD-L1表达.
主要方法:
- 对23例巨细胞泌尿腺癌病例的回顾性分析.
- 组织病理学检查,包括评估线粒体数字和分离差异化.
- 对于尿路细胞标记物,Ki67,p53和PD-L1.1的免疫组织化学染色.
主要成果:
- 在所有病例中,巨细胞成分在10-30%之间,与高度泌尿腺癌有关.
- 35%的患者出现了晚期疾病,12%的患者在诊断时有远程转移.
- 观察到较低整体和癌症特异性存活率的趋势,特别是在T1阶段,与传统泌尿腺癌相比.
- 发现了高基67的扩散 (平均71%) 和p53的积累 (平均64%). PD-L1表达是可变的.
结论:
- 巨细胞泌尿瘤是一种与高级临床阶段相关的独特亚型.
- 这种亚型显示出对生存结果较差的趋势.
- 需要进一步的研究,以了解这种罕见的癌症的特定生物学和治疗策略.
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