在为慢性髓性白血病治疗博苏替尼的患者的管理中的实际考虑
Jeffrey H Lipton1, Tim H Brümmendorf2,3, Kendra Sweet4
1Princess Margaret Cancer Centre, Toronto, Canada. jeffreyhlipton@gmail.com.
Annals of hematology
|July 18, 2024
概括
治疗慢性髓性白血病 (CML) 的氨酸激酶抑制剂博苏替尼的不良事件 (AEs) 管理至关重要. 剂量调整和支持性护理有效地管理副作用,改善患者的坚持和结果.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 血液学 血液学 血液学
背景情况:
- 博苏替尼是第二代氨酸激酶抑制剂 (TKI),用于治疗费城染色体阳性慢性髓性白血病 (CML).
- 随着TKIs的出现,不良事件 (AEs) 很常见,因此需要有效的管理策略,以确保患者遵守治疗并获得最佳的患者结果.
研究的目的:
- 为医生提供有关预防和管理博苏替尼相关副作用的最新实用信息.
- 根据最新的证据和临床经验,审查博苏替尼的剂量策略.
主要方法:
- 关于博苏替尼安全性的已发表证据和临床经验的审查.
- 临床研究和实践数据对博苏替尼治疗的分析.
- 检查用于管理AE的剂量调整策略.
主要成果:
- 博苏替尼 (bosutinib) 显示出普遍有利的安全性概况,在不同治疗线和长期报告中一致.
- 剂量调整 (起始剂量修改和/或治疗期间的修改) 是管理副作用和改善耐受性的关键策略.
- 使用博苏替尼的AE管理与用于CML治疗的其他TKIs相似.
结论:
- 通过治疗修改和支持性护理,博苏替尼的安全概况是可以管理的.
- 在管理毒性和个性化剂量方法方面的经验增加可以提高患者的坚持和治疗结果.
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