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在技术上不可切除的中度发达口腔癌中对新辅助化疗的反应的评估

Abhishek Kadian¹, Puneet Takkar², Ankit Sharma³

¹Department of Surgery Army College of Medical Sciences, New Delhi, India.

Journal of cancer research and therapeutics

|July 18, 2024

概括

新辅助化疗 (NACT) 在47%的患者中有效地将不可切除的口腔癌转化为可手术的疾病. 这种治疗没有增加手术并发症,这表明它在治疗晚期口腔癌的价值.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
医学瘤学医学瘤学

背景情况:

先进的口腔癌带来了严重的治疗挑战,预后不佳.
新辅助化疗 (NACT) 正在探索,以减少瘤的体积,并促进手术切除.

研究的目的:

评估NACT在将无法切除的口腔癌转化为可操作的状态中的有效性.
评估NACT后的临床和病理反应率.

主要方法:

具有二次数据分析的前性观察研究.
纳入30名接受NACT治疗的中度晚期口腔癌患者 (2014年11月至2016年4月).
对患者人口统计,化疗方案,毒性,反应率和手术结果的分析.

主要成果:

在46.67%的患者中,NACT实现了切除能力.
总体响应率为31%,临床和病理响应之间存在显著的关联.
发烧性中性质减退发生在10%的患者中,手术并发症的增加没有.

结论:

NACT有效地使无法切除的口腔癌变得可操作.
NACT表明临床和病理反应之间存在显著的相关性.
在患有口腔癌的患者中,NACT不会提高手术并发症率.

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