p16,p53和EGFR表达在头部和部状细胞癌中及其与临床病理学参数的相关性
Shalini Gupta1,2, Pinki Pandey2, Sakshi Verma2
1Department of Pathology, Metropolis Healthcare Pvt. Ltd, New Delhi, India.
Journal of cancer research and therapeutics
|July 18, 2024
概括
评估了p16,人类乳头瘤病毒 (HPV) 的标志物,以及p53和EGFR的瘤抑制剂在头部和部状细胞癌 (HNSCC) 中. 它们的表达与临床因素相关,有助于评估瘤的攻击性.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 口腔状细胞癌 (HNSCC) 是癌症死亡的一个重要原因.
- 人类乳头瘤病毒 (HPV) 16型与HNSCC的病因有关.
- 在状细胞癌中,p16表达作为HPV感染的替代标记.
- p53瘤抑制基因功能障碍和EGFR过度表达与HNSCC进展和预后不佳有关.
研究的目的:
- 为了研究p16,p53和EGFR在HNSCC中的表达.
- 为了将p16,p53和EGFR表达与临床病理学参数相关联.
- 检查p16,p53和EGFR表达之间的关系.
主要方法:
- 一项横截面的观察性研究包括100例HNSCC病例.
- 使用免疫组织化学染色来确定p16,p53和EGFR表达.
- 使用统计分析 (千平方测试) 来评估相关性,P<0.05被认为是显著的.
主要成果:
- 分别在60%,44%和58%的病例中表达了p16,p53和EGFR.
- p16表达与年龄,瘤部位,性习惯和淋巴结参与有显著的关联.
- 与年龄和性习惯相关的p53表达.
- 在p16与p53的免疫组织化学表达和EGFR之间发现了显著的相关性.
结论:
- 免疫组织化学p16表达是HPV的可靠替代标记物.
- 评估p16,p53和EGFR表达为评估HNSCC的攻击性提供了有价值的信息.
- 这些信息可以帮助临床医生为HNSCC患者选择合适的治疗方式.
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