在癌症患者的肺部内输液内输液内输液内输液内输液nivolumab
Ilya Tsimafeyeu1, Vadim Goutnik2, Igor Shrainer3,4
1Bureau of Cancer Research, Moscow, Russia.
Journal of cancer research and therapeutics
|July 18, 2024
概括
在癌症患者中,单次内灌注nivolumab对预防内溢血复发无效. 虽然耐受性很好,但在这项初步研究中没有显示出显著的疗效.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 肺疾病 肺疾病
背景情况:
- 恶性肺溢液是转移性癌症的常见并发症.
- 目前对恶性多流的治疗有局限性.
- 免疫疗法药物的脑内灌注正在作为一种新的治疗策略进行探索.
研究的目的:
- 评估nivolumab在大多溢液中的初步疗效和毒性.
- 为了评估治疗后3个月的无复发存活率.
- 为了确定nivolumab在这个患者群体中的腹腔内安全概况.
主要方法:
- 在胸腔切除术后,单次内灌注尼沃卢马布 (40毫克) 进行.
- 符合条件的患者患有转移性癌症,患有需要疏散的大型肺溢液.
- 主要终点是3个月的无复发生存期;13名患者被纳入.
主要成果:
- 没有观察到有效性,导致研究在第一阶段后终止.
- 54%的患者 (7/13) 在3个月内经历了多流的复发.
- 没有发现任何不良事件;所有患者在1个月内没有复发,喘息或咳.
结论:
- 40毫克的nivolumab单次内灌注在防止内溢血复发方面无效.
- 在癌症患者中,肌内输液的肌内输液耐受性很好.
- 对替代剂量或组合疗法的进一步研究可能是有必要的.
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