上腺素与上腺素对在脊髓麻醉下进行剖腹产的患者的前血栓反应产生影响:一项随机,双盲,受控研究
Wenhui Tao1,2, Jinfeng Bao3, Yufang Xie3
1Department of Anesthesiology, The Second Affiliated Hospital of Anhui Medical University.
International journal of surgery (London, England)
|July 18, 2024
概括
上腺素 (NE) 不会使剖腹产前血栓反应恶化,可能比上腺素 (PHE) 更安全. NE输液增加了凝血因子,可能有助于高出血风险的妇女的血液静止.
科学领域:
- 麻醉学 麻醉学
- 产科 产科 产科 产科 产科
- 药理学 药理学是指药理学的学科.
背景情况:
- 静脉血栓栓塞是剖腹产的一个严重并发症.
- 众所周知,上腺素 (NE) 可以激活凝血通路.
- 了解预防性血管压缩剂对凝血的影响对于患者安全至关重要.
研究的目的:
- 为了比较预防性上腺素 (NE) 与上腺素 (PHE) 输注在脊髓麻醉下的剖腹产期间对前血栓反应的影响.
- 评估这些药物对凝血因子和标记物的影响.
主要方法:
- 一项随机研究涉及66名在脊髓麻醉下进行剖腹产的妇女.
- 参与者从操作开始到操作结束时都接受了固定速率的NE或PHE输液.
- 在手术前和后测量了凝血因子VIII活性 (FVIII:C),纤维素和D-二聚合物的血水平.
主要成果:
- 手术后的纤维素和D-二次体水平与NE组的手术前水平没有显著差异,尽管FVIII:C下降了.
- 与PHE组相比,NE组的FVIII:C,纤维素和D-二聚合物的术后水平增加.
- 这些发现表明,与PHE相比,NE具有促凝效应.
结论:
- 上腺素 (NE) 似乎不会对剖腹产期间母亲的血栓前反应产生负面影响.
- 与PHE相比,NE输液导致凝血分子水平增加,这表明在显著的手术内出血的情况下,对血液静止有潜在的益处.
- 在剖腹产期间,NE可以被认为是管理低血压的安全选择.
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