皮层发育和进化的原理
1State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Neurology, Institutes of Brain Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. yangz@fudan.edu.cn.
Neuroscience bulletin
|July 18, 2024
概括
大脑的进化变化导致了大脑的变化.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 进化生物学 进化生物学
背景情况:
- 人类的认知能力源于大脑皮层的进化.
- 皮层发育依赖于放射性质细胞,这是主要的神经干细胞.
- 了解这些细胞是理解大脑演变的关键.
研究的目的:
- 审查哺乳动物皮层辐射质细胞的生物学和进化.
- 为皮层神经发生进化提出一个基因渐进的过程.
- 探索皮层进化和矮化背后的分子机制.
主要方法:
- 对哺乳动物皮层辐射质细胞现有文献的综述.
- 对细胞外信号调节激酶 (ERK) -骨形态蛋白7 (BMP7) -GLI3抑制剂形式 (GLI3R) -声波刺 (SHH) 途径的分析.
- 假设皮层进化和矮体的分子机制.
主要成果:
- 在皮层神经发生过程中确定了一个核心分子通路 (ERK-BMP7-GLI3R-SHH反循环).
- 建议增加放射性质中的SHH信号作为皮质进化矮体的原因.
- 挑战了SHH在灵长类动物皮层扩张中的作用和在皮层进化中的人类特异基因.
结论:
- 皮层神经发生是通过一个涉及核心分子通路的基因渐进过程进化而来的.
- SHH信号对抗ERK-BMP7信号,导致皮质矮化.
- SHH信号传递和人类特异性基因可能不是灵长类人皮层扩张或人类大脑进化的主要驱动因素.
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