免疫疗法与肝细胞癌患者的最佳支持性护理与儿童皮格B功能障碍患者的最佳支持性护理
Claudia Angela Maria Fulgenzi1,2, Bernhard Scheiner1,3, Antonio D'Alessio1,4
1Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, England.
JAMA oncology
|July 18, 2024
概括
与最佳支持性护理 (BSC) 相比,基于免疫检查点抑制剂 (ICI) 的疗法显著改善了无法切除的肝细胞癌 (uHCC) 和Child-Pugh B级肝功能障碍患者的整体存活率. 这一发现为这种患者群体的积极治疗提供了关键证据.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 患有Child-Pugh B级 (CP-B) 肝功能障碍的不可切除的肝细胞癌 (uHCC) 提出了治疗挑战.
- 在这个人群中,积极的抗癌治疗与最佳支持性护理 (BSC) 的益处仍在争论中.
研究的目的:
- 评估基于免疫检查点抑制剂 (ICI) 的疗法与HHCC和CP-B肝功能障碍患者的整体存活率 (OS) 的相关性.
- 为了将基于ICI的疗法与BSC进行比较,对于这个患者队列.
主要方法:
- 追溯,多中心,国际临床病例系列.
- 将187名接受一线ICI治疗的患者与156名接受BSC治疗的患者进行比较.
- 倾向性得分匹配用于控制基线特征.
主要成果:
- 在ICI组 (7.50个月) 中,与BSC组 (4.04个月) 相比,ICI组的中位寿命显著更长.
- ICI暴露与~50%的死亡风险降低有关 (HR,0.55;P <.001).
- 门静脉瘤血栓形成和高AFP水平等因素与死亡风险增加有关.
结论:
- 与BSC相比,ICI治疗对HHCC和CP-B肝功能障碍患者的生存益处更高.
- 这项研究提供了比较证据,支持在这个具有挑战性的患者群体中使用基于ICI的疗法.
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