健康的产前饮食模式和后代自闭症
Catherine Friel1, Alastair H Leyland1, Jana J Anderson2
1MRC/CSO Social and Public Health Sciences Unit, University of Glasgow, Glasgow, Scotland.
JAMA network open
|July 18, 2024
概括
健康的产前饮食与儿童自闭症诊断和社交沟通困难的几率较低有关. 这一发现支持了母亲营养对神经发育结果的重要性.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 神经发育障碍 神经发育障碍
背景情况:
- 产前饮食在自闭症谱系障碍 (ASD) 中的作用被建议,但由于小型的回顾性研究,缺乏强有力的证据.
- 不一致的发现凸显了需要进行大规模的前性研究,以澄清母亲的饮食和ASD之间的关联.
研究的目的:
- 为了检查产前饮食模式和自闭症诊断之间的关系,在两个大,潜在的出生队伍.
- 调查怀孕期间母亲饮食与自闭症相关特征之间的关联,包括社交沟通困难和重复行为.
主要方法:
- 利用了挪威母亲,父亲和儿童队列研究 (MoBa) 和父母和儿童的艾文纵向研究 (ALSPAC) 的数据.
- 包括通过食物频率调查问卷自我报告的饮食数据的单独怀孕.
- 分析后代的结果,包括自闭症诊断和社会沟通得分,使用通用非线性模型,直到8岁.
主要成果:
- 对健康的产前饮食模式的高度坚持与儿童中自闭症诊断 (OR,0.78) 和社交沟通困难的几率降低有关.
- 在MoBa中观察到自闭症诊断和MoBa和ALSPAC中社交沟通困难的特定关联.
- 在健康的产前饮食和限制性或重复性行为之间没有发现一致的关联.
结论:
- 坚持健康的产前饮食模式与自闭症诊断和社交沟通困难的可能性较低有关.
- 这些发现强调了母亲营养对儿童神经发育的潜在影响.
- 进一步的研究可能会探索特定的饮食成分及其对自闭症相关特征的影响.
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