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Updated: Jun 12, 2026

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在直肠癌中对新辅助放射治疗进行分层,按治疗方案和转录特征进行分层

Umair Mahmood1, Andrew Blake1, Sanjay Rathee1

  • 1Department of Oncology, Medical Science Division, University of Oxford, Oxford, United Kingdom.

Cancer research communications
|July 18, 2024
PubMed
概括

瘤免疫和 stromal 签名预测直肠癌对新辅助化学放射治疗的反应. 放射性敏感性特征 (RSS) 预测了反应,而氧沙可能会改善瘤丰富的瘤的结果.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...