意大利西北部COVID-19住院患者的多病症分析:使用进化机器学习和卫生行政数据进行纵向研究
Dayana Benny1,2, Mario Giacobini3, Alberto Catalano1,4
1Centre for Biostatistics, Epidemiology, and Public Health, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
JMIR public health and surveillance
|July 18, 2024
概括
多种疾病增加了COVID-19的严重性风险. 机器学习识别了与住院相关的特定药物和疾病组合,有助于脆弱人群的风险评估.
科学领域:
- 流行病学 流行病学
- 机器学习 机器学习
- 公共卫生 公共卫生
背景情况:
- 多病性,即多种疾病的共存,是严重的公共卫生问题.
- 它与增加COVID-19风险和减少预期寿命有关.
- 管理用于风险评估的多病态数据是具有挑战性的,因为数据稀疏性和组合复杂性.
研究的目的:
- 根据年龄和性别,评估多病症患者的COVID-19严重程度.
- 开发一个进化机器学习模型来处理数据稀疏性,并识别关键的多病症组合.
- 使用阿普里奥里算法识别与COVID-19住院相关的高支持多病性特征组合.
主要方法:
- 利用了来自意大利皮埃蒙特地区的12,793名 (年龄在45-74岁之间) COVID-19 患者的行政数据.
- 提取了COVID-19前5年的病史,包括药物处方和诊断.
- 采用了具有5倍交叉验证的进化深度学习模型和Apriori算法进行分析.
主要成果:
- 确定了与COVID-19住院相关的特定多病症预测因素.
- 关键特征包括年龄>53,葡萄糖皮质体吸入剂,其他抗药,比古安胺/甲福林,阿尼利德,其他阿片类药物,抑制尿酸产生的制剂和不同队列的α-上腺受体对抗剂.
- 这些组合表明更严重的COVID-19结果.
结论:
- 甚至更不常见的医疗条件,当结合起来时,显示与COVID-19结果的关联.
- 重新利用的行政数据可以提高COVID-19之外的弱势群体的风险评估.
- 该研究强调了将多病症数据纳入流行病学风险评估的重要性.
关键词:
在ATC中,ATC是ATC.在 COVID-19 疫情中,在ICD的基础上,ICD是ICD.意大利意大利意大利意大利意大利意大利这就是SARS-CoV-2病毒.大数据就是大数据.冠状病毒冠状病毒病毒数据数据的数据数据的数据.数据分析数据分析数据分析数据挖掘是数据挖掘的一个方法.流行病学流行病学进化算法是一种进化算法.功能垃圾桶 功能垃圾桶功能工程的特点工程.健康数据健康数据长时间的COVID.纵向分析 纵向分析纵向分析是一种纵向分析.纵向研究是一种纵向研究.机器学习是机器学习.多病态性多病态性多种药房多种药房公共卫生公共卫生.风险评估 风险评估 风险评估进行风险评估,评估风险.严重程度的严重程度.稀疏的二进制数据稀疏的二进制数据.相关概念视频
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