瘤微环境响应的细胞透:设计原理和精确传递
Chenhui Wang1, Bo Wang1, Qing Zhang2
1Department of Cell Biology, School of Medicine, Nankai University, Tianjin 300071, China.
Colloids and surfaces. B, Biointerfaces
|July 18, 2024
概括
细胞透 (CPPs) 提供细胞内传递,但缺乏选择性. 响应瘤微环境 (TME) 的CPP正在开发中,用于精确地输送纳米药物和抗癌药物.
科学领域:
- 生物医学工程 生物医学工程
- 药物运输 药物运输 药物运输
- 纳米技术纳米技术
背景情况:
- 细胞透 (CPPs) 促进细胞内传递,但往往缺乏标选择性.
- 有限的选择性阻碍了CPPs用于纳米医学和抗癌药物输送的临床翻译.
- 响应瘤微环境 (TME) 的策略正在出现,以提高CPP的选择性.
研究的目的:
- 审查CPPs的细胞吸收机制.
- 讨论TME响应CPP的设计原则和精确交付.
- 总结各种类型的刺激反应性CPP及其在纳米医学和抗癌药物输送中的应用.
主要方法:
- 对CPP和TME响应激活策略的文献进行系统审查.
- 单刺激响应,多刺激响应,TME响应向和可逆激活的CPP (RACPP) 的分类和总结.
- 讨论对TME响应性CPPs的纳米医学和翻译应用.
主要成果:
- CPP细胞吸收机制的详细概述.
- 九个单一刺激响应,五个多重刺激响应,三个TME响应向和两个RACPP的综合摘要.
- 探索用于纳米医学应用和抗癌药物输送的对TME敏感的CPP.
结论:
- 对TME敏感的CPP代表了选择性药物输送的重大进步.
- 下一代可激活CPP (ACPP) 对向的纳米医学和抗癌疗法具有前景.
- 对TME响应性CPP的进一步研究可以克服临床翻译当前的局限性.
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