双重玻璃化和胚胎囊的加热不会影响怀孕,流产或活产率
Balsam Al Hashimi1, Elena Linara-Demakakou2, Simon C Harvey3
1London Women's Clinic, London, UK.; School of Biosciences, University of Kent, Canterbury, Kent, UK..
Reproductive biomedicine online
|July 18, 2024
概括
双胞胎胚胎玻璃化,这是一种涉及冷和重新冷胚胎的过程,在植入前遗传测试 (PGT-A) 后不会对怀孕,流产或活产率产生负面影响. 这一发现为辅助生殖技术提供了保证.
科学领域:
- 生殖科学 生殖科学
- 胚胎学 胚胎学
- 遗传学 遗传学 是一个
背景情况:
- 辅助生殖技术 (ART) 经常涉及胚胎冷保存.
- 胚胎移植前遗传检测 (PGT-A) 是一种在移植前对胚胎进行的常见程序.
- 重复的玻璃化和升温周期对胚胎活力和随后的妊娠结果的影响需要仔细评估.
研究的目的:
- 调查双胞胎胚胎玻璃化和加热是否会影响经过PGT-A的胚胎的怀孕,流产或活产率.
- 评估双玻璃化对出生结果的影响,包括出生体重和妊娠期.
主要方法:
- 一个回顾性观察分析,比较了84个双玻璃化胚胎囊与729个单玻璃化胚胎囊.
- 胚胎在培养5-7天后被玻璃化,双重玻璃化包括加热,活检和重新玻璃化.
- 进行了单个胚胎移植,并比较了两组之间的结果.
主要成果:
- 双玻璃化和单玻璃化组之间的怀孕,流产或活产率没有显著差异 (55%对56%).
- 后勤回归确定了母亲的年龄,更长的培养时间和较低的胚胎质量作为减少活产率的预测因素,但不是双玻璃化.
- 双玻璃化胚胎后来被冷,并且比单玻璃化胚胎扩大了更多.
结论:
- 双胞胎胚胎玻璃化似乎不会对关键的生殖结果产生负面影响,例如PGT-A后的怀孕,流产或活产率.
- 初步数据表明对流产率,出生体重或妊娠期没有不良影响,尽管需要使用更大的样本大小进行进一步的研究.
- 这些发现为涉及PGT-A.的ART协议中的双玻璃化安全性和有效性提供了保证.
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