白质超强度与老年人没有痴呆症的慢步速度有关
Juan P Vazquez1,2, Joe Verghese3,4, Nir Barzilai3,5
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, jvazqu17@jh.edu.
Neuro-degenerative diseases
|July 18, 2024
概括
大脑小血管疾病 (CSVD) 的负担,特别是白质超强度 (WMH),与老年人的正常步行速度减缓有关. 这种关联在基底,叶和额叶中被观察到,但不是复杂的行走任务.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 放射学 放射学是一门学科.
背景情况:
- 缓慢的步行速度是老龄化人口健康状况不佳的重要指标.
- 老年人脑小血管疾病 (CSVD) 病理与步行速度之间的确切关系仍然不完全理解.
- 调查CSVD成像标志物与简单 (正常步行 (NPW)) 和复杂 (走路时说话 (WWT)) 步态的关系至关重要,因为它们与诸如落,虚弱,残疾,死亡率和痴呆症等不良健康结果的共同关联.
研究的目的:
- 检查在没有痴呆症的老年人中,在NPW和WWT期间特定的CSVD成像标志物和步行速度之间的关联.
- 为了确定白质超强度 (WMH) 和缺口的位置和模式是否影响步行速度.
- 了解CSVD对简单和复杂的行走任务的影响.
主要方法:
- 一组113名阿什基纳兹犹太成年人65岁以上,没有痴呆症,接受了评估.
- 白质超强度 (WMH) 和缺口使用FLAIRMRI图像的既定评级系统来量化.
- 根据年龄,性别,总体健康状况和内体积进行调整的线性回归模型用于分析CSVD标记物与步行速度 (NPW和WWT) 之间的关联.
主要成果:
- 在基底和叶增加的WMH与较慢的NPW速度有显著的关联.
- 较高的CSVD负担,其特点是前叶和全球的汇流扩散WMH,与减少的NPW速度相关.
- 没有发现WMH或缺口和WWT速度之间,也没有发现缺口和NPW速度之间有显著的关联.
结论:
- 较高的CSVD负担,由WMH在基底和叶中表明,与老年人的正常步伐步行速度较慢有关.
- 前额叶的流动-扩散WMH与较慢的平均正常步行速度特别相关.
- 这些发现表明,CSVD主要影响简单的步行速度,对复杂的步行任务没有观察到影响,需要进一步研究时间性和机械联系.
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