建伟小洋颗粒通过调节HIF-1α-VEGF通路来改善慢性缩性胃炎
Jia Liu1, Mengyu Li2, Guobao Chen1
1Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin, 214400, Jiangsu Province, China.
Journal of ethnopharmacology
|July 18, 2024
概括
建伟小洋颗粒 (JWXYG) 通过通过HIF-1α-VEGF通路抑制血管生成来治疗慢性缩性胃炎 (CAG). 这项研究阐明了JWXYGG.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
- 胃肠病学 胃肠病学
背景情况:
- 伟小洋颗粒 (JWXYG) 是一种传统的中医药,用于慢性缩性胃炎 (CAG).
- 关于JWXYG对CAG的物质基础和治疗机制尚不清楚.
研究的目的:
- 研究JWXYG在治疗慢性缩性胃炎 (CAG) 的物质基础和潜在机制.
主要方法:
- 在HPLC-Q-TOF-MS/MS分析中,确定了JWXYG组件.
- 在体内 (大鼠CAG模型) 和体内 (MNNG诱导的MC细胞) 的研究评估了JWXYG的疗效.
- 网络药理学预测了机制,得到了西方斑点,免疫组织化学和免疫光学的验证.
- 分子对接阐明了潜在的治疗化合物.
主要成果:
- 惠普LC-Q-TOF-MS/MS确定了31个JWXYG成分,包括阿尔比佛洛林和佩奥尼佛洛林.
- 治疗JWXYG显著改善了大鼠的CAG,并抑制了MNNG诱导的MC细胞进展.
- 在CAG大鼠胃组织中,JWXYG抑制了HIF-1α,VEGF和VEGFR2的高表达.
结论:
- 通过通过HIF-1α-VEGF通路抑制血管生成,JWXYG对CAG表现出治疗作用.
- 这项研究阐明了JWXYG用于CAG治疗的机制和材料基础.
- 提供实验数据,支持JWXYG的合理临床应用.
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