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肺动脉大小和脉冲率的新型参考方程使用心声学及其在肺高血压的诊断价值

Shadi P Bagherzadeh¹, Bettia E Celestin², Everton J Santana³

¹Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA.

|July 18, 2024

概括

根据高度索引的主要肺动脉 (MPA) 大小的新参考限值,改善了肺高血压 (PH) 诊断. 透气中MPA直径显示了检测PH的最高诊断值.

科学领域:

心血管成像 - 心血管成像
肺高血压的诊断肺高血压的诊断
心声回声扫描 (Echocardiography) 是一种心声回声扫描.

背景情况:

目前的肺高血压 (PH) 准则表明,在胸前心声扫描上,主要肺动脉 (MPA) 的直径>25毫米支持PH诊断.
肺动脉 (PA) 的大小可以根据身体大小,年龄和心脏阶段而异,可能会影响诊断的准确性.

研究的目的:

为了建立PA大小的参考限值,使用跨胸腔心声学,考虑到身体大小,性别和年龄.
评估PA大小的诊断价值,以对PH进行分类.
评估参考组选择 (健康患者与导管患者) 如何影响诊断概率比率 (DOR).

主要方法:

分析了248名健康个体的参考队列和693名PH患者和156名非PH患者的队列 (通过右心导管检查证明).
主肺动脉 (MPA) 和右肺动脉直径/区域使用心声回声仪进行测量.
量子回归分析得出了高度指数的参考限值 (第5至95百分位数) 和诊断几率比率 (DOR).

主要成果:

高度指数的MPA直径的第95百分位为15mm/m (腹缩) 和19mm/m (心缩) 在两种性别.
年龄对MPA直径的影响很小.
腹痛中MPA直径显示为检测1组PH的最高DOR (156.2),与对照组相比,对2组和3组PH也观察到显著的DOR.

结论:

基于高度索引和量子力回归,已经建立了MPA大小的新参考限值.
这些新的参考限值提高了肺高血压的心声回声学诊断能力.

关键词:

贝叶斯统计学贝叶斯统计学条件建模有条件建模发现疾病的检测.诊断几率比率是诊断几率的比率.诊断研究诊断研究超声心电图 (Echocardiography) 是一种心声回声仪.肺高血压是一种肺高血压.参考方程参考方程参考方程

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