在患有功能衰竭的患者中使用塞马格卢提德 - - 一项回顾性队列研究
Jane J Long1, Sukhdeep S Sahi2, Adley I Lemke3
1Department of Surgery, Mayo Clinic, Rochester, Minnesota.
概括
在晚期慢性病 (CKD) 中使用塞马格卢提德 (GLP-1 RA) 有望减轻体重和改善血糖控制,尽管有胃肠道副作用,但大多数患者都能耐受药物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 作为GLP-1受体激动剂的塞马格卢提德,已被批准用于糖尿病和体重管理.
- 有限的数据存在于semaglutide在晚期慢性病 (CKD) 的使用.
研究的目的:
- 评估塞马格卢提德在患有晚期CKD (4期或以上) 或透析患者的安全性和有效性.
- 评估结果,包括体重变化,血糖控制和不良事件.
主要方法:
- 对于先进的CKD患者的电子病历的回顾性分析,该病例是从塞马格卢提德 (口服或注射) 开始的.
- 从2018年1月到2023年1月收集的数据.
- 统计分析包括费舍尔的精确测试,配对的t测试,线性混合效应模型和威尔科克森的签名排名测试.
主要成果:
- 包括76名晚期CKD患者;大多数患有2型糖尿病 (96%) 和男性 (53.9%).
- 平均体重下降了4.6% (P < .001),HbA1c从8.0%降至7.1% (P < .001). 平均体重下降了4.6% (P < .001),HbA1c从8.0%降到了7.1% (P < .001). 平均体重下降了4.6%,HbA1c从8.0%降到了7.1% (P < .001).
- 63.1%的人没有报告任何不良反应;导致停药的常见副作用是恶心,吐和腹痛.
结论:
- 在晚期的CKD患者中,塞马格卢提德似乎可以耐受,改善血糖控制并帮助T2DM中断胰岛素.
- 观察到适度的体重减轻.
- 需要进行更大规模的前性研究来确认这种人群的风险和益处.
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