在FTO介导的RNAm6中,甲基化调节了类风湿性关节炎中的突侵略和炎症

Ruiru Li1, Yu Kuang1, Yuanyuan Niu2

  • 1Department of Rheumatology and Immunology, the First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan Er Road, Guangzhou 510080, Guangdong Province, China.

概括

脂肪质量和与肥胖相关的蛋白质 (FTO) 通过调节N6-甲基氨酸 (m6A) 修饰,驱动类风湿性关节炎 (RA) 炎症和关节损伤. 抑制FTO可以降低RA的严重程度,这表明FTO是潜在的治疗标.

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