重度抑郁症缓解期患者的功能:系统性审查和元分析
Rasmus Schwarz1, Klaus Munkholm2, Mie S Christensen3
1Mental Health Centre Northern Zealand, The Early Multimodular Prevention and Intervention Research Institution (EMPIRI) - Mental Health Services CPH, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Journal of affective disorders
|July 18, 2024
概括
大型抑郁症 (MDD) 患者表现出全球功能受损,即使在缓解期. 这凸显了需要持续评估MDD管理中的运作.
科学领域:
- 神经科学和行为科学 神经科学和行为科学
- 临床心理学 临床心理学
- 精神病学是一个精神病学.
背景情况:
- 大型抑郁症 (MDD) 代表了全球严重的健康负担.
- 了解MDD患者在缓解期间的功能障碍对于有效管理至关重要.
研究的目的:
- 与健康对照组 (HC) 相比,系统地审查和元分析MDD成年人完全或部分缓解的全球功能.
- 评估MDD患者在康复期间功能障碍的程度.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 在PubMed,EMBASE和PsycINFO (1980-2023) 中进行了搜索.
- 包括42项研究 (17,999名MDD患者,35,550名HC患者);使用JBI检查清单评估方法质量;使用随机效应模型计算标准化平均差异 (SMD).
主要成果:
- 与HC (SMD -2.00,95%CI: -0.9至 -3.03) 相比,在完全或部分缓解的MDD患者中,整体功能显著降低.
- 分析包括14项研究中的15项比较,包括MDD和HC组.
结论:
- 患有MDD的患者表现出降低的全球功能水平,即使在缓解期.
- 功能评估应该是MDD管理的组成部分,包括在缓解阶段.
- 限制包括研究参与者的不清楚或缺失的报告以及大多数纳入研究中的设置信息.
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