相关实验视频
Updated: Jun 20, 2025
![An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F66708.jpg&w=3840&q=50)
10:33
An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
747
FAPI最近的临床影响:成像和治疗
Mahshid Kiani1, Safura Jokar1, Leila Hassanzadeh2
1From the Department of Nuclear Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Clinical nuclear medicine
|July 18, 2024
概括
纤维细胞激活蛋白 (FAP) 成像显示出用于诊断和治疗癌症和非恶性疾病的前景. 针对FAP的PET成像增强了瘤检测和监测治疗反应,提供了新的诊断和治疗途径.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 分子成像学分子成像学
背景情况:
- 纤维细胞激活蛋白 (FAP) 在癌症相关纤维细胞 (CAF) 和各种非恶性疾病中过度表达.
- 在瘤微环境中,FAP至关重要,影响瘤的增殖,侵袭,血管生成,免疫抑制和耐药性.
研究的目的:
- 提供FAP在癌症和非恶性疾病中的作用的全面概述.
- 讨论用于成像和治疗的FAP抑制剂,包括临床影响和挑战.
- 在非恶性疾病中呈现68Ga-FAPI-46的成像结果.
主要方法:
- 对FAP在疾病病理生理学中的功能进行审查.
- 对放射性标记的FAP抑制剂的分析,重点是小分子.
- 在患有非恶性疾病的患者中对68Ga-FAPI-46进行临床成像和生物分布研究.
主要成果:
- 针对FAP的成像,特别是PET,在检测FAP表达瘤方面表现出高灵敏度和特异性.
- 针对心脏FAP的成像可能成为管理左心室重塑的新生物标志物.
- 68Ga-FAPI-46成像显示了非恶性疾病的潜力,如间歇性肺病和心肌梗塞.
结论:
- FAP抑制剂代表了癌症和非恶性疾病的诊断和治疗的有希望的目标.
- 针对FAP的成像可以改善瘤检测,分期和治疗监测.
- 对FAP抑制剂的进一步研究为个性化医学提供了重要的前景.
相关概念视频
01:29Positron Emission Tomography
4.1K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.1K
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
90
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
90
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
95
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
95