在学习感官歧视任务时,杏仁体和皮质的关系.
1Department of Medical Neurobiology, Faculty of Medicine, The Institute for Medical Research Israel-Canada (IMRIC), The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
概括
学习塑造大脑活动,将感官输入与奖励联系起来. 在感官区分任务中,皮层-杏仁核连接会加强,杏仁核反应会出现并与运动和奖励预期相关联.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 学习和记忆的学习和记忆
背景情况:
- 在感官学习过程中,皮层和皮下区域表现出复杂的动态.
- 杏仁体和皮质将刺激与奖励联系起来,并参与运动反应.
- 在学习过程中皮质 - 杏仁体关系的发展仍然不清楚.
研究的目的:
- 为了研究皮质-杏仁体关系的出现,在学习的感官歧视任务.
- 在学习过程中同时记录皮质和杏仁核中的人口动态.
主要方法:
- 在雄性小鼠中使用了广场皮质成像和纤维光度学.
- 从后皮层和基底侧桃体 (BLA) 或中央/中部桃体 (CEM) 进行了同时记录.
- 小鼠学会了依赖胡须的去/不去任务.
主要成果:
- 在学习之前,只有皮质对感觉做出反应;杏仁核没有显著的反应.
- 有了专业知识,杏仁体反应在感觉期的早期出现,CEM增加,BLA减少.
- 皮层-杏仁核活动与与任务相关的运动相关,在之前约200 ms.
结论:
- 学习导致皮质-杏仁体相互作用的动态变化.
- 中部/中部桃体 (CEM) 显示参与度增加,而底侧桃体 (BLA) 显示参与度减少.
- 这些神经变化可能会促进感官刺激与适当结果的关联.
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