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积极监测前列腺癌是否变得更安全? 从全球临床注册表中吸取的经验教训
Chris Bangma1, Paul Doan2, Lin Zhu3
1Department of Urology, Erasmus Medical Centre Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
European urology oncology
|July 18, 2024
概括
积极监测 (AS) 是一种安全有效的策略,用于管理低风险和中等风险的前列腺癌,表现出良好的长期结果和高生存率.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 公共卫生 公共卫生
背景情况:
- 主动监测 (AS) 是低风险和中等风险前列腺癌的常见管理策略.
- 对AS的长期安全性和结果数据对于指导临床实践至关重要.
研究的目的:
- 评估前列腺癌积极监测的长期安全性,可接受性和治疗结果.
- 分析大型国际队列中的生存率和治疗进展情况.
主要方法:
- 分析了来自15个国家的25个队伍中26999名AS男性的临床数据.
- 从2000年开始在国际数据库中收集的数据,随访时间超过6年.
主要成果:
- 随着时间的推移,整体存活率 (OS) 没有显著变化.
- 无转移存活率 (MFS) 改善,并保持优异 (>99%).
- 10年总生存率为84.1%,无转移生存率为99.4%.
结论:
- 积极监测是低风险和中等风险前列腺癌的安全管理选择,具有良好的长期结果.
- 新的诊断工具可以提高AS的接受度,并可能将其应用扩展到更高风险的病例.
- 10年后,20%的低风险病例和31%的中等风险病例开始接受治疗.
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