对腺病毒载体疫苗的直接先天性免疫反应的纵向多基因分析和皮质类固醇调节
Seong Jin Choi1, Wonhyo Lee2, Sang Cheol Kim3
1Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea.
Vaccine
|July 18, 2024
概括
像ChAdOx1 nCoV-19这样的黑猩猩腺病毒 (ChAd) 载体疫苗可以引起炎症反应. 口服皮质类固醇可以减少这些副作用而不影响疫苗的有效性,提供了潜在的缓解策略.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 分子生物学分子生物学
背景情况:
- 黑猩猩腺病毒载体疫苗ChAdOx1 nCoV-19对于全球COVID-19控制至关重要,因为其成本低,不需要冷藏.
- 立即的炎症反应是ChAdOx1 nCoV-19疫苗接种初始剂量后常见的.
研究的目的:
- 为了研究ChAdOx1 nCoV-19疫苗接种后的免疫反应.
- 确定减轻疫苗引起的炎症副作用的策略.
主要方法:
- 来自免疫细胞的单细胞转录组的分析.
- 疫苗接种后单细胞的表观遗传学概况.
- 对皮质类固醇治疗前对免疫反应和疫苗免疫性影响的评估.
主要成果:
- 接种疫苗后一天,观察到表达干扰素刺激基因 (ISG) 的单细胞和T细胞群的短暂增加,到第14天恢复到基线.
- 用口服皮质类固醇进行预治疗显著降低了与ISG相关的炎症反应.
- 皮质类固醇治疗没有影响疫苗免疫性.
结论:
- 接种ChAdOx1 nCoV-19疫苗会引起一种独特的,短暂的免疫反应,其特征是ISG激活.
- 口服皮质类固醇是一种可行的方法,可以在不影响疗效的情况下减轻基于ChAd的疫苗的炎症副作用.
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