患者报告的结果对认知功能障碍进行查,并预测肝硬化患者的入院情况
Avesh J Thuluvath1, Minjee Kim2, John Peipert3
1Northwestern University Transplant Outcomes Research Collaborative (NUTORC), Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA; Department of Medicine, Feinberg School of Medicine, Division of Gastroenterology and Hepatology, Northwestern University, Chicago, Illinois, USA.
Transplantation proceedings
|July 18, 2024
概括
一个简单的调查有效地选肝硬化患者的肝脑病变 (HE). 患者报告的认知功能预测住院,为管理这种常见并发症提供了一种实用工具.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 神经科学是一个神经科学.
- 临床医学 临床医学
背景情况:
- 肝脑病变 (HE) 是肝硬化的一个常见的严重并发症,导致住院和死亡.
- 由于时间,设备和人员的限制,目前的HE查方法未得到充分利用.
- 有效的HE查对于改善患者的治疗结果和减少医疗保健负担至关重要.
研究的目的:
- 研究患者报告的认知功能与肝硬化患者客观认知措施之间的关联.
- 为了确定患者报告的认知功能是否可以预测肝硬化患者住院的情况.
- 评估一个简短的患者报告结果测量信息系统 (PROMIS) 调查对HE查的有用性.
主要方法:
- 一项单中心前性研究招募了接受肝移植评估的成年患者.
- 用国家卫生研究院工具箱认知电池和PROMIS认知功能调查 (PROMISCF) 来评估认知功能.
- 进行了相关性和多变量分析,以评估PROMISCF和认知测试之间的关系,并预测住院情况.
主要成果:
- 23名肝移植候选人被录取,平均MELD-Na得分为14.9.
- PROMISCF分数与列表排序工作记忆测试有显著的相关性 (r = 0.45,P = .03).
- PROMISCF是总住院日数 (P < .001),住院次数 (P = .01) 和住院率 (P < .001) 的重要预测因素.
结论:
- 一个简短的PROMIS认知功能调查可以有效地选肝硬化患者的HE.
- 通过PROMISCF测量患者报告的认知功能,准确地预测未来的住院治疗.
- 这份简短的调查提供了一个实用且易于使用的工具,用于在临床环境中进行常规的HE查和管理.
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