滴滴微流体法用于估计离子交联酸微球的动态界面张力
Alexander Ashikhmin1,2, Maxim Piskunov1,2, Dmitry Kochkin3
1School of Energy and Power Engineering, Tomsk Polytechnic University, 30, Lenin Ave., Tomsk 634050, Russia.
Langmuir : the ACS journal of surfaces and colloids
|July 18, 2024
概括
这项研究优化了使用滴滴微流体学的水凝微球生产. 一种新的方法预测了界面张力,使得3D打印设备能够高效地制造制药和生物工程微球.
科学领域:
- 生物材料科学 生物材料科学
- 化学工程是化学工程的重要组成部分.
- 微流体学 微流体学
背景情况:
- 水凝微球对于制药和生物工程应用至关重要.
- 优化它们的生产,特别是控制界面张力,是高效制造的关键.
- 目前的方法可能需要额外的后期生产步骤,增加复杂性.
研究的目的:
- 开发一种半经验方法,用于预测水凝微球形成中的动态界面张力.
- 设计和优化微流体装置,以高效,单步水凝微球生产.
- 为了简化制造过程,用于制药和生物工程应用.
主要方法:
- 在一个定制设计的同轴装置中利用滴滴微流体,使用3D打印制造.
- 开发了一种半经验模型,将雷诺兹和奥尼索尔格数结合起来,以预测界面张力.
- 采用了Young-Laplace和形下降方法来确定界面张力和接触角度.
主要成果:
- 成功预测了离子交联酸微球-向日油界面的动态界面张力.
- 展示了一种在3D打印设备内单一步生产完全交叉连接的微球的方法.
- 验证了特定流速的预测方法,实现了76.5 ± 0.3 mN/m的最终界面张力.
结论:
- 开发的半经验方法可靠地预测了界面张力,从而实现了优化的水凝微球生产.
- 3D打印技术为制造微球制造的微流体设备提供了负担得起和有效的方法.
- 这项研究提供了一种精简的高科技方法,用于生产用于生物工程和制药用途的交联聚合物微球.
相关概念视频
02:57Surface Tension, Capillary Action, and Viscosity
Surface Tension
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
The various IMFs between identical molecules of a substance are examples of cohesive forces. The molecules within a liquid are surrounded by other molecules and are attracted equally in all directions by the cohesive forces within the liquid. However, the molecules on the surface of a liquid are attracted only by about one-half as many molecules. Because of the unbalanced molecular attractions on the surface molecules, liquids contract to form a shape that minimizes the number...
01:13Excess Pressure Inside a Drop and a Bubble
The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops.
01:24Surface Tension
Surface tension is defined as the force per unit length (γ) acting along the surface of a liquid. It arises due to strong intermolecular forces of attraction. A molecule located inside the bulk of the liquid is surrounded by other molecules and experiences equal forces in all directions. However, a molecule at the surface experiences unbalanced forces because there are more neighboring molecules below than above. This creates a net inward force that pulls surface molecules toward the interior,...
01:22Surface Tension of Fluid
Surface tension is a fundamental property of fluids, occurring at the boundary between a liquid and a gas or between two immiscible liquids. This phenomenon arises from the cohesive forces between molecules at the fluid's surface, creating an effect similar to a stretched elastic membrane. Inside each fluid, molecules are equally attracted in all directions by neighboring molecules, but surface molecules experience a net inward force, resulting in surface tension.
Surface tension varies with...
Surface tension varies with...