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在动物模型中,一个鼻腔纳米粒子STING激动剂可以保护动物免受呼吸道病毒的影响

Ankita Leekha¹, Arash Saeedi¹, Monish Kumar¹

¹William A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, USA.

Nature communications

|July 18, 2024

概括

纳米STING是一种新型免疫激活剂,提供广泛的保护,防止SARS-CoV-2和流感等呼吸道病毒. 这种纳米粒子疗法在临床前模型中证明了安全性和有效性,为新疗法铺平了道路.

科学领域:

免疫学免疫学免疫学
纳米技术纳米技术
病毒学病毒学

背景情况:

呼吸道病毒感染对全球健康造成重大负担.
新兴的病毒变种由于免疫扩散性质,挑战了疫苗的疗效.
需要有效的,现成的治疗方法来对抗呼吸道病毒.

研究的目的:

开发和评估纳米STING,一个纳米颗粒配方的STING激动剂2'-3'cGAMP,作为一个广泛的抗病毒疗法.
在临床前模型中评估NanoSTING对SARS-CoV-2和流感病毒的安全性和有效性.

主要方法:

在纳米颗粒中封装的2'-3'cGAMP使用NanoSTING进行了配方.
在鼻内注射后,在小鼠和大鼠中评估了安全性.
在对抗SARS-CoV-2 (Alpha,Delta,Omicron变种) 的有效性进行了测试,对象是子和小鼠的流感病毒.
在仓鼠模型中评估了阻断传输的潜力.
机理学研究涉及分析小鼠,仓鼠和非人类灵长类动物的免疫通路激活.

主要成果:

在动物模型中,NanoSTING证明了安全性.
单次鼻内注射剂量保护了仓鼠免受SARS-CoV-2Alpha和Delta变异的影响.
纳米STING减少了Omicron变种在仓鼠中的传播.
在小鼠中观察到对奥塞塔米维尔敏感和耐药流感菌株的保护.
纳米STING在不同物种中调节了干扰素依赖和独立的免疫通路.

结论:

纳米STING是一种安全有效的广泛免疫激活剂,可对抗呼吸道病毒.
这种基于纳米粒子的疗法对控制由SARS-CoV-2和流感引起的感染具有前景.
纳米STING代表了一种潜在的新疗法策略,用于管理呼吸道病毒性疾病.

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