带状神经系统的进化起源由两虫的发育轨迹揭示出来
Yichen Dai1,2, Yanhong Zhong1, Rongrong Pan1
1State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Nature ecology & evolution
|July 18, 2024
概括
研究两类细胞类型揭示了三条状神经元的古老发育路径,揭示了脊椎动物神经系统起源. 这项研究确定了神经细胞进化的保存和新机制.
科学领域:
- 进化发育生物学 进化发育生物学
- 进行比较的基因组学.
- 神经科学是一个神经科学.
背景情况:
- 脊椎动物的神经系统是从一个复杂的共同祖先进化而来的,但其多样化的细胞类型的起源仍然不完全理解.
- 阿姆菲奥克斯 (Amphioxus) 是一种非脊椎动物的带动物,由于其遗传位置,它为早期的带动物和脊椎动物进化提供了关键的见解.
研究的目的:
- 为了阐明状细胞类型的进化和追踪脊椎动物神经细胞类型的起源,使用amphioxus作为模型.
- 识别有助于神经系统形成的保存和新发育途径.
主要方法:
- 单细胞RNA测序跨越七个amphioxus胚胎阶段.
- 细胞轨迹的祖先-后代重建.
- 转录因子基因表达动态的推断.
- 用突变线来对关键神经特异因子进行功能分析.
主要成果:
- 鉴定新型的两细胞类型,包括脊椎动物下丘脑和神经细胞的同类.
- 发现了三种不同的发育途径,用于状神经元的形成.
- 保存的前部FoxQ2依赖的神经发育机制的特征,一个不太保存的后部脊髓通路,以及一种特定于状动物的神经元细胞原生机制.
结论:
- 脊椎动物的神经系统源于至少三个古老的发育策略.
- 干带动物中神经体祖先的进化显著影响了后部神经和中皮细胞的发育和身体的延长.
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