在胸部CT检测到的间歇性肺异常的患病率和进展率:系统性审查和元分析
Jisun Hwang1, Seulgi You2, Ye Jin Lee3
1Department of Radiology, Ajou University School of Medicine, Suwon, Republic of Korea.
间歇性肺异常 (ILAs) 影响约9.7%的人. 大约一半的ILA患者呈现放射性进展,特别是那些有纤维化的ILA患者在更长的随访期间.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 流行病学 流行病学
背景情况:
- 间歇性肺异常 (ILAs) 在临床实践中越来越多地得到认可.
- 有限的基于人口的数据存在关于ILAs的流行和进展.
研究的目的:
- 为了确定ILAs的综合流行率和进展率.
- 确定与ILAs放射性进展相关的风险因素.
主要方法:
- 在EMBASE和PubMed上进行了系统的文献搜索,截至2023年5月10日.
- 采用随机效应模型,将患病率,进展率和进展率的几率比率结合起来.
- 亚组分析比较了一般和高风险肺癌人群;研究质量使用偏差风险工具进行评估.
主要成果:
- 19项研究 (241,541名患者) 报告了9.7%的集成ILA患病率.
- 十项研究 (1317名患者) 显示,综合进展率为47.1%,随着更长的随访 (≥4.5年) 显著提高.
- 纤维化ILA显示进展的几率增加了5.55倍 (OR,5.55;95% CI,1.95-15.82).
结论:
- 据估计,ILA的患病率为9.7%.
- 大约一半的ILA患者经历了放射性进展,随着时间的推移,其比例会增加.
- 纤维性ILA是疾病进展的重要危险因素.
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