作为紧急手术患者死亡率预测指标的catecholamine度
João Isuk Suh1, Daiane Leite da Roza2, Filipe Matheus Cadamuro3
1Nephrology Division, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.
International journal of emergency medicine
|July 18, 2024
概括
血清上腺素和上腺素水平与手术患者的衰老和死亡率有关. 在老年人中无法检测到的上腺素可能会预测更高的死亡率,这表明使用上腺素在休克中可能有好处.
科学领域:
- 临界护理医学 临界护理医学
- 外科手术的结果
- 创伤中的生物标志物
背景情况:
- 创伤和紧急手术对患者的发病率和死亡率有很大影响.
- 衰老是影响手术结果和生存率的关键因素.
研究的目的:
- 调查血清上腺和上腺水平与手术患者的衰老和死亡率之间的关联.
- 确定潜在的生物标志物,用于预测创伤和紧急手术的结果.
主要方法:
- 在外科重症监护病房进行前性观察队列研究.
- 包括90名接受重大创伤或术后护理的患者.
- 收集人口统计学,临床变量和血清中甲醇胺水平 (上腺素,上腺素).
主要成果:
- 在60岁以上的患者中,未检测到的上腺素与使用血管活性药物有关 (OR=6.36,p=0.05).
- 在无法检测到上腺素的患者中,较高的上腺素水平 (≥2006.5 pg/mL) 与增加的住院死亡率相关 (OR=4.00,p=0.03).
结论:
- 高龄化和死亡风险增加之间存在关联.
- 不能检测到的血清上腺素,在老年人中更为普遍,可能表明结果较差.
- 上腺素的使用可能会改善老年手术患者遭受冲击的预后.
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