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肠道微生物对晚期腺瘤的风险的影响

Zhuang Jing^1,2,3, Wu Zheng^1,2,3, Song Jianwen^1,2,3

¹Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, Zhejiang Province, China.

BMC microbiology

|July 18, 2024

概括

特定的肠道微生物,包括Prevotella sp900557255和Felixounavirus,在晚期腺瘤 (AA) 中升高. 这些微生物显示出作为早期AA检测和改善风险预测的非侵入性生物标志物的潜力.

科学领域:

微生物组研究的研究.
胃肠病学胃肠病学
在瘤学瘤学.

背景情况:

大肠直肠癌 (CRC) 主要源于晚期腺瘤 (AA).
肠道微生物失调症与AA和CRC的发展有关.

研究的目的:

识别与晚期腺瘤 (AA) 相关的特征性肠道微生物.
评估这些微生物作为AA检测的非侵入性生物标志物的潜力.

主要方法:

来自92名AA患者和184名对照的便微生物群的高通量测序.
使用R-vegan包对α和β多样性的分析.
开发用于AA风险预测和亚型分类的机器学习模型.

主要成果:

在AA中观察到的细菌 (Prevotella sp900557255,Alistipes putredinis,Megamonas funiformis) 和病毒 (Lilyvirus,Felixounavirus,Drulisvirus) 的丰度增加.
在预测AA风险方面,Catboost模型取得了很高的准确性 (87.27%的细菌,83.33%的病毒).
根据细菌和病毒资料确定了四种不同的亚型 (B1V1,B1V2,B2V1,B2V2),提高了预测准确度.

结论:

普雷沃特拉sp900557255和菲利克索纳病毒显示出对AA的早期预警有显著的潜力.
肠道微生物代表了AA诊断的有希望的非侵入性生物标志物.
肠道微生物的亚型增强了AA预测模型的准确性.

关键词:

在先进的腺瘤中.肠道病毒肠道病毒肠道细菌是什么肠道细菌是什么大基因组测序的测序.预测模型的预测模型.

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