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内源性雌激素和大脑激活在口头记忆编码和认知在绝经后的过程中
Rachel A Schroeder1, Rebecca C Thurston2, Minjie Wu3
1Department of Psychology, University of Illinois at Chicago, Chicago, IL 60612, USA.
The Journal of clinical endocrinology and metabolism
|July 19, 2024
概括
绝经后雌激素水平会影响记忆任务期间的大脑活动. 较高的雌激醇 (E2) 可能通过在编码过程中改善时间和额叶皮质功能来增强口头记忆.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 认知心理学 认知心理学
背景情况:
- 在更年期期间,口头记忆力下降是常见的.
- 内源性雌激素在认知功能中发挥作用.
- 了解雌激素对绝经后大脑的影响至关重要.
研究的目的:
- 为了确定内源性雌激素 (雌激醇和雌激素) 与绝经后大脑的记忆系统之间的关联.
- 评估这些关联的临床意义.
- 在口头记忆任务中调查雌激素水平与大脑网络连接之间的关系.
主要方法:
- 对199名绝经后妇女 (MsBrain队列) 的横截面研究.
- 血清雌激醇 (E2) 和雌激素 (E1) 通过LC-MS/MS测量.
- 在口头记忆任务 (编码和识别) 期间进行功能磁共振成像 (fMRI).
- 大脑激活与记忆,抑郁和焦虑的神经心理测量指标的关联.
主要成果:
- 雌激醇 (E2) 在编码过程中与时和额叶皮层激活积极相关.
- 在编码过程中,雌激素 (E1) 与双边上时和右上额的激活有关.
- 在特定区域 (例如,左下额头,左中额头,左上状) 的大脑激活与记忆性能,抑郁和焦虑有关.
- 在E1和记忆性能之间没有发现显著的关联.
结论:
- 对于记忆功能至关重要的大脑区域根据更年期后雌激素水平表现出不同的活性.
- 较高的雌醇水平可以通过改善时间和额叶皮层功能来增强口头记忆编码.
- 雌激素对大脑网络连接的影响即使在更年期后的低水平上也是显著的.
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