种族差异,肺癌风险,以及NRF2基因多态与基于凝的化疗的关联
Tirumalasetty Devika1, Ganesapandian Mahalakshmi2, K Mythili3
1Department of Pharmacology, Guntur Medical College, Guntur, IND.
Cureus
|July 19, 2024
概括
在NRF2基因的遗传变异没有显著影响肺癌的风险或结果在南印度患者接受凝胺化疗. 这项研究没有发现与治疗反应,毒性或存活率的相关性.
科学领域:
- 药物基因组学 药物基因组学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 肺癌,特别是非小细胞肺癌,是一个重大的全球健康挑战.
- 吉姆西塔化疗是一种广泛使用的治疗方法,但其疗效受到影响,因为影响其代谢途径的遗传变异.
- 了解这些遗传多态性对于预测耐药性,毒性和患者结果至关重要.
研究的目的:
- 研究南印度患者NRF2基因遗传变异与肺癌风险之间的关联.
- 评估这些NRF2基因变异在预测基因反应,毒性和基因基因基因治疗的患者的生存中的作用.
主要方法:
- 在南印度的184名健康志愿者和123名癌症患者中使用RT-PCR进行了NRF2单核酸多态 (SNP) rs6721961的基因定型.
- 使用RECIST标准评估瘤反应,通过CTCAE v4.03评估毒性,通过随访分析评估存活率.
- 与全球人口 (EUR,AFR,AMR,EAS) 进行了对比.
主要成果:
- NRF2-617 C>A (rs6721961) 的小等位基因频率在健康人群中为12.8%,在癌症患者中为14.2%,频率与南亚和欧洲人群相似,但与非洲,美国和东亚人群不同.
- 研究的NRF2 SNP与肺癌风险之间没有发现显著的关联.
- 在肺癌患者中,没有观察到NRF2变体与治疗反应,毒性或存活率之间的相关性.
结论:
- 尽管NRF2基因具有多方面的作用,但在研究的南印度人群中,NRF2基因与肺癌风险没有显著联系.
- 研究的NRF2基因变体没有影响对基于凝胺的化疗的反应,也没有预测毒性或生存结果.
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