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深度大脑刺激对帕金森病中泌尿器官功能的影响:系统性审查和元分析

Long Gao¹, Meng Wang², Mengdi Zhou²

¹Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, China.

Frontiers in neurology

|July 19, 2024

概括

深度大脑刺激 (DBS) 改善了帕金森病患者的尿液储存和排泄功能,但没有显著影响性功能. 这项研究提供了对DBS泌尿器官影响的见解.

科学领域:

神经学神经学
泌尿器科泌尿器科泌尿器科泌尿器科
医学研究医学研究

背景情况:

深度大脑刺激 (DBS) 是对帕金森病运动症状的主要治疗方法.
在帕金森病患者中,DBS对泌尿器官系统的影响仍在调查中.
泌尿器官功能障碍是帕金森病中常见的非运动性症状,影响生活质量.

研究的目的:

系统地评估DBS对帕金森病患者尿液储存,排泄和性功能的影响.
通过对相关研究进行元分析,综合现有证据.
为了全面了解DBS对泌尿器官的影响.

主要方法:

在PubMed,Embase,Cochrane图书馆,科学网和Scopus进行了全面的文献搜索.
包括到2024年2月27日发表的研究,重点关注帕金森病患者的DBS和泌尿器官功能.
对14项选定的研究进行了元分析.

主要成果:

DBS与尿急性减少 (OR=1.85) 和最大膀容量增加 (MD=-66.10) 相关.
在最大流量 (MD=-0.64),空隙后残留 (MD=-6.79) 和最大流量 (MD=-1.37) 期间的破坏器压力 (MD=-1.37) 中观察到显著改善.
在性功能方面没有发现显著差异 (MD=-1.41).

结论:

在帕金森病中,DBS对尿液储存和排泄功能有好处.
一些泌尿动力学参数和分数没有显示DBS的统计学上显著的变化.
在男性帕金森病患者中,DBS似乎没有显著影响勃起功能.

关键词:

帕金森病是帕金森氏症的一种疾病.深度大脑刺激刺激大脑下泌尿道的症状下泌尿道的症状性功能性功能性功能性功能性功能性功能系统性审查系统性审查泌尿器官功能泌尿器官功能

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