相关实验视频

Updated: Jun 20, 2025

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
12:07

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

14.0K

使用基于双向变压器的化学语言模型扩展具有强效化合物的多站点模拟系列

Hengwei Chen1, Atsushi Yoshimori2, Jürgen Bajorath1,3

  • 1Department of Life Science Informatics and Data Science, B-IT, LIMES Program Unit Chemical Biology and Medicinal Chemistry, University of Bonn Friedrich-Hirzebruch-Allee 5/6 D-53115 Bonn Germany bajorath@bit.uni-bonn.de +49 228 7369 100.

RSC medicinal chemistry
|July 19, 2024
PubMed
概括

这项研究引入了一种新型的变压器模型,用于在不断变化的化学模拟系列中预测强效化合物,解决药物化学中的一个关键挑战. 该方法成功地为复杂的多站点系列生成了具有更高功率的新类型.

更多相关视频

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels11:19

Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels

Published on: July 4, 2016

10.6K
A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression11:23

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

10.2K

相关概念视频

Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
4.8K