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Updated: Jun 23, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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瘤亚型分类工具用于HPV相关的头癌

Shiting Li1, Bailey F Garb1, Tingting Qin1

  • 1Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA.

bioRxiv : the preprint server for biology
|July 19, 2024
PubMed
概括

一个新的机器学习分类器准确地将人类乳头瘤病毒阳性头支状细胞癌 (HPV+ HNSCC) 分为IMU和KRT分子亚型. 这种工具有助于了解不同的瘤特征和潜在的治疗策略.

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Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
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Classification of Epithelial Tissues: Glandular Epithelium

The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...