一个共享的威胁预测电路在不同时刻被某些和不确定的威胁动态地启动
Brian R Cornwell1, Paige R Didier2, Shannon E Grogans2
1Department of Psychological & Brain Sciences, George Washington University, Washington, DC 20006 USA.
bioRxiv : the preprint server for biology
|July 19, 2024
概括
恐惧和焦虑共享大脑电路,但它们的神经动态不同. 杏仁体的中心核对不确定的威胁表现出持续的反应,而结核的床核对某些威胁表现出阶段性反应.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 情感研究 情感研究
背景情况:
- 传统模型根据威胁特征区分恐惧 (阶段性) 和焦虑 (持续性).
- 这些独特的情绪反应的神经生物学基础,特别是在扩展的杏仁体内,仍在争论中.
研究的目的:
- 研究威胁预测的神经动态及其与恐惧和焦虑的关系.
- 澄清在威胁处理中,末 (BST) 的床核和杏仁体 (Ce) 中央核的不同作用.
主要方法:
- 在220名成年人中利用功能磁共振成像 (fMRI) 以理论驱动的建模方法.
- 采用了感兴趣的解剖区域来分析中央扩展桃体 (EAc) 分区 (BST和Ce) 的激活模式.
- 使用经过验证的多维素大脑"签名"来追踪预期痛苦的时刻动态.
主要成果:
- 在确定和不确定的威胁预测期间,一个共享的神经回路,包括EAc,近水管灰色,中和前面的岛屿,都被招募.
- 这个电路显示了对不确定的远距离威胁的持续激活和对某些迫在眉的威胁的短暂爆发.
- 与流行的模型相反,Ce对不确定的威胁表现出持续的激活,而BST对某些威胁表现出阶段性激活.
结论:
- 威胁预测神经激活动态反映了主观的痛苦经历.
- 这些发现挑战了现有的模型,通过在EAC分类中展示了独特的,但重叠的恐惧和焦虑的神经特征.
- 提供了对威胁处理和情绪神经生物学的新见解,为未来的临床研究铺平了道路.
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