硫氨基酸受体合导电量改变了北极瘤中两个中央模式生成电路的性能
Sonal Kedia1, Naziru M Awal1, Jackie Seddon1
1Biology Department and Volen Center, Brandeis University, Waltham, MA 02454.
bioRxiv : the preprint server for biology
|July 19, 2024
概括
硫尿素受体 (SUR) 将细胞能量水平与神经元活动联系起来. 在类动物中,SURs独特地控制了不同神经网络中的爆发,影响着对新陈代谢状态的反应.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
背景情况:
- 神经元功能依赖于电活动和能量供应之间的平衡.
- 硫尿素受体 (SURs) 是一种ATP结合盒蛋白,直接将细胞代谢与离子通道活性联系起来.
- 在不同神经元电路中SUR的特定作用及其对网络输出的影响仍然不完全理解.
研究的目的:
- 研究能量可用性对北极 (Cancer borealis) 中央模式发生器 (CPG) 的影响.
- 描述不同CPG中的SUR相关导电量的生物物理性质和功能影响.
- 阐明SUR如何调解神经网络对代谢状态的反应.
主要方法:
- 对SUR相关通道的药理学操纵,用于北极瘤*的胆囊和心脏.
- 分析神经元发射模式和刺激性,以应对SUR调制.
- 调查SUR导电的生物物理,包括通道透性和灵敏度.
主要成果:
- SUR操纵在口腔胃 (STG) 和心脏 (CG) 中产生了相反的效果.
- 在STG中,打开SUR相关通道通过降低pyloric扩展器神经元刺激性来抑制神经元发射.
- 在CG中,打开与SUR相关的道增加了爆发中的发射,而关闭它们则减缓了爆发.
结论:
- 与SUR相关的导电量为神经元提供了一个共同的机制,以对能量可用性作出不同的反应.
- 确定了新的SUR导电生物物理学,以类似于哺乳动物系统的方式影响神经元活动.
- 这些发现凸显了代谢传感在调节各种神经网络功能的关键作用.
更多相关视频
07:48Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
Published on: December 26, 2016
11.3K
05:51Coculture Analysis of Extracellular Protein Interactions Affecting Insulin Secretion by Pancreatic Beta Cells
Published on: June 15, 2013
12.9K
相关概念视频
Oral Hypoglycemic Agents: Sulfonylureas
199
Sulfonylureas are oral hypoglycemic agents utilized in treating type 2 diabetes. They are characterized by their unique sulfonylurea chemical structure. The family of sulfonylureas is divided into generations. First-generation sulfonylureas, including tolbutamide (Orinase), chlorpropamide (Diabinese), and tolazamide (Tolinase), trigger insulin release from pancreatic β cells and enhance peripheral tissues' insulin sensitivity. The second-generation members, such as glipizide...
199
Transducer Mechanism: Enzyme-Linked Receptors
2.4K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.4K
GPCRs Regulate Adenylyl Cylase Activity
5.4K
Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.4K
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Inhibition of Cdk Activity
4.7K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.7K
G Protein-coupled Receptors
11.7K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
11.7K
