患有儿科固体瘤的患者肠道微生物组的特征
Xiaoran Du1, Xu Cui1, Rongrong Fan1
1Pediatric Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in pediatrics
|July 19, 2024
概括
小儿固体瘤患者与健康儿童相比,表现出明显的肠道微生物群差异. 关键的细菌群体如细菌和肠球菌的水平升高,而其他细菌群体的水平降低,为儿童癌症研究提供了新的见解.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 儿科 儿科 儿科
背景情况:
- 儿科固体瘤 (PST) 是一个重要的儿童恶性瘤.
- 肠道微生物组在成人瘤中的作用已经确立,但其对儿科癌症的影响还未得到充分研究.
研究的目的:
- 调查和描述儿科固体瘤患者和健康对照人群之间的肠道微生物组合的差异.
主要方法:
- 招募了23名PST患者和20名健康对照 (HC).
- 收集了43个便样本进行分析.
- 进行了16S rRNA测序,以分析肠道微生物群.
主要成果:
- 与HC相比,PST患者表现出改变的肠道微生物多样性和组成.
- 在PST患者中观察到 *Bacilli* 和 *Enterococcus* 的显著丰富.
- 在PST患者中,发现了包括*Lachnospiraceae未分类*,*Lachnospira*,*Haemophilus*和*Colidextribacter*在内的属的丰度减少.
结论:
- 这项研究为小儿固体瘤患者的肠道微生物群提供了第一个特征.
- 在PST患者和健康儿童之间存在肠道微生物群组成的显著差异.
- 这些发现凸显了肠道微生物组在儿科固体瘤中的潜在作用.
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