饮食和营养补充剂与结直肠癌之间的关联:系统性审查
Maryam Gholamalizadeh1, Shirin Tajadod2, Nazanin Majidi3
1Student Research Committee, Cancer Research Center Shahid Beheshti University of Medical Sciences Tehran Iran.
概括
饮食补充剂,如长链n-3多不和脂肪酸 (n-3 LCPUFA) 和益生菌,可能有助于降低结肠直肠癌 (CRC) 风险. 需要更多的研究来确认这些发现,并了解它们是如何工作的.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 结肠直肠癌 (CRC) 是一个全球性的健康问题.
- 营养摄入量和CRC发展之间的关系尚未完全理解.
研究的目的:
- 审查关于饮食摄入量/补充剂与CRC发生之间的关联的现有文献.
- 确定特定营养素和补充剂对CRC的潜在保护作用.
主要方法:
- 从1990年到2023年,对主要数据库 (PubMed,Scopus,科学网,科克兰图书馆) 的系统文献搜索.
- 包括检查饮食因素和CRC风险的临床试验和队列研究.
主要成果:
- 长链n-3多不和脂肪酸 (n-3 LCPUFA) 显示出降低CRC风险的潜力 (8/12研究呈阳性).
- 益生菌,益生菌和协生菌的结果各不相同,一些研究表明它们具有抑制作用.
- 对于维生素D,叶酸,和等微量营养素降低CRC风险的证据是不确定的.
结论:
- 某些食补充剂,包括n-3 LCPUFA和益生菌,可能会对CRC提供保护性益处.
- 需要进一步的研究来验证这些潜在的益处,并阐明潜在的生物机制.
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