身体活动,长期细颗粒物暴露和2型糖尿病发病率:一个前性队列研究
Qian Li1,2, Fangchao Liu2,3, Keyong Huang2,3
1Department of Epidemiology, Center for Global Health, School of Public Health Nanjing Medical University Nanjing Jiangsu China.
身体活动 (PA) 可能不会在高细颗粒物 (PM2.5) 暴露的地区预防2型糖尿病. 高水平的PM2.5可以减少或否定PA的健康益处,特别是对于长期居住者.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 环境细颗粒物 (PM2.5) 对2型糖尿病产生不利影响.
- 身体活动 (PA) 在控制2型糖尿病方面起着有益的作用.
- 与2型糖尿病风险相关的PM2.5暴露和PA之间的相互作用尚未得到充分理解.
研究的目的:
- 调查PM2.5对PA和2型糖尿病风险之间的关联的影响.
- 评估PM2.5暴露是否会改变PA对2型糖尿病的保护作用.
主要方法:
- 这项前性研究涉及71,689名参与者.
- 通过问卷评估的PA (体积和强度).
- 使用卫星数据 (1公里分辨率) 估计的长期PM2.5暴露.
- 考克斯的比例危险模型用于分析关联.
主要成果:
- 在低PM2.5区域,更高的PA体积与降低2型糖尿病风险相关 (HR=0.75).
- 在高PM2.5区域,更高的PA体积没有显著降低2型糖尿病风险 (HR=1.10).
- 高度的PM2.5暴露与最高的PA水平相结合,显著增加了2型糖尿病的风险 (HR=1.79为体积,HR=1.82为强度).
结论:
- 在低污染环境中,PA对2型糖尿病的保护作用显而易见.
- 高度的PM2.5暴露可以减弱或逆转PA的好处.
- 对于居住在长期污染地区的人来说,需要仔细评估PA的健康益处.
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