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Updated: Jun 20, 2025

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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PIM1-HDAC2轴通过表观遗传修饰来调节肠道平衡

Jianming Yang1, Yawen Xiao1, Ningning Zhao1

  • 1Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, the Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Immunology, School of Basic Medical Sciences, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin Key Laboratory of Cellular and Molecular Immunology, Tianjin Medical University, Tianjin 300070, China.

Acta pharmaceutica Sinica. B
|July 19, 2024
PubMed
概括

莫洛尼小鼠白血病病毒-1 (PIM1) 基因酶的前病毒整合部位在结肠炎中升高,减少了杯状细胞. 这种PIM1-HDAC2轴会损害肠道屏障的完整性,并促进结肠炎相关的结肠直肠癌.

关键词:
在 CAC CAC CAC 中.表观遗传修饰是一种表观遗传修饰.玻璃杯细胞是一个杯细胞.我们的肠道微生物群.在 HDAC2 中,HDAC2 是肠道恒常性 肠道恒常性在PIM1中,PIM1是PIM1.性结肠炎是一种

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