单域抗体作为固体瘤治疗的治疗药物
Mingkai Wang1,2, Tianlei Ying1,2, Yanling Wu1,2
1MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Department of Pulmonary and Critical Care Medicine, Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Acta pharmaceutica Sinica. B
|July 19, 2024
概括
来自驼或鱼的单域抗体 (sdAbs) 与传统抗体相比,具有治疗优势. 人性化技术正在克服其动物起源,使得癌症治疗中的新应用成为可能.
科学领域:
- 生物技术是生物技术.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 单域抗体 (sdAbs),也称为纳米体或VNARs,来自驼和鱼.
- 与传统抗体相比,它们具有优越的物理化学和药理性质,包括小尺寸,高溶解度,热稳定性和增强的组织透性.
- 然而,由于其潜在的免疫性,它们的动物起源给临床应用带来了挑战.
研究的目的:
- 提供单域抗体 (sdAbs) 的综合性审查.
- 为了突出sdAb人性化技术的进步.
- 探索基于sdAb的治疗方法的治疗潜力和最近的进展,特别是对于固体瘤.
主要方法:
- 对单域抗体 (sdAbs) 现有文献的审查.
- 对各种人性化技术的分析,包括CDR接种和人类SDAbs的全面工程.
- 审查sdAb药物合物,多种类型的sdAbs,基于sdAb的输送系统和细胞疗法的最新发展.
主要成果:
- sdAbs在治疗应用中表现出有利的特性.
- 人性化策略有效地解决了与sdAbs.相关的免疫性问题.
- 新兴的基于sdAb的疗法在固体瘤治疗中显示出显著的潜力.
结论:
- 单域抗体 (sdAbs) 是一种具有独特优势的有前途的治疗类.
- 人化对于它们的临床转化和广泛应用至关重要.
- 基于sdAb的策略为癌症治疗和药物输送提供了创新的方法.
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
01:27Tumor Immunotherapy
504
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
504
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:31Hybridoma Technology
14.4K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
14.4K