莫尔努皮拉维尔在患有精神疾病的患者治疗COVID-19的有效性
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Ting-Hui Liu1, Hsuan-Yi Liao1, Chih-Cheng Chang1,2
1Department of Psychiatry, Chi Mei Medical Center, Tainan, Taiwan.
Frontiers in pharmacology
|July 19, 2024
概括
对于非住院的COVID-19患有精神疾病的患者,molnupiravir治疗减少了住院和死亡风险. 它还降低了COVID-19后疾病的发生率,包括疲劳和认知症状.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 精神病学是一个精神病学.
背景情况:
- COVID-19 带来了重大风险,特别是对于那些已经患有精神疾病的人来说.
- 对于临床决策至关重要的是要了解像molnupiravir这样的抗病毒治疗在这个脆弱人群中的有效性.
- 这项研究解决了关于molnupiravir对非住院COVID-19患者的短期和长期结果的影响的证据需求.
研究的目的:
- 调查molnupiravir在非住院COVID-19患者的临床有效性,这些患者有先前存在的精神疾病.
- 评估molnupiravir对短期结果 (住院治疗或死亡) 和COVID-19后长期状况的影响.
主要方法:
- 一个回顾性队列研究,利用TriNetX研究网络.
- 纳入标准:2022年1月至2023年5月期间,非住院COVID-19患者患有精神疾病.
- 倾向性得分匹配 (PSM) 用于比较用摩尔努皮拉维尔治疗的患者与未接受治疗的对照组 (每组9,421名患者).
主要成果:
- 莫尔努皮拉维尔治疗与30天内因任何原因住院或死亡的风险显著降低相关 (HR,0.760;95% CI,0.665-0.869).
- 在接受治疗的组中观察到多达一年的各种后COVID-19疾病风险降低,包括胸部/喉疼痛,呼吸异常,疲劳,认知症状和肌痛.
- 在molnupiravir组中风险降低的特定COVID-19后疾病包括:胸部/喉疼痛 (HR,0.615),呼吸异常 (HR,0.761),疲劳 (HR,0.718),认知症状 (HR,0.769) 和肌痛 (HR,0.647).
结论:
- 莫尔努皮拉维尔可能与非住院COVID-19患者患有精神疾病的住院或死亡率较低有关.
- 这些发现表明,molnupiravir在降低这种患者群体患COVID-19后疾病的风险方面具有潜在的益处.
- 需要进一步的研究来证实这些发现,并探索molnupiravir在治疗COVID-19患者的长期影响.
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