探讨握力强度与不良怀孕和围产期结果之间的关联:孟德尔随机化研究
Yanpeng Wang1, Yinzhen Zhang1, Wenhai Zhao2
1Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, 130117, China.
Heliyon
|July 19, 2024
概括
孕妇的握力增加可能会对后代的出生体重产生积极影响,这表明在怀孕期间有潜在的保护作用. 这一发现凸显了监测母亲握力的重要性,以改善围产期结果.
科学领域:
- 产科和妇科 产科和妇科
- 遗传学 是一个遗传学.
- 围产儿医学 围产儿医学
背景情况:
- 观察性研究表明,母亲的握力与不良妊娠结果之间存在联系.
- 握力和怀孕结果之间的因果关系尚不清楚.
研究的目的:
- 调查握力与不良怀孕/周产期结果之间的因果关系.
- 为针对握力强度的干预提供证据,以改善怀孕健康.
主要方法:
- 使用双样本的门德尔随机化方法与英国生物银行和FinnGen数据.
- 采用逆方差加权作为主要分析方法.
- 进行敏感性分析 (Cochran's Q,MR-Egger,留出一个,漏斗图) 以确保结果的有效性.
主要成果:
- 基因预测的更高的手握强度与后代出生体重有显著的积极关联.
- 左手握力 (β=0.193) 和右手握力 (β=0.310) 都与出生体重有正相关.
- 灵敏度分析证实了研究结果的稳定性,没有证据表明类或偏差.
结论:
- 握力与后代的出生体重有因果关系,可能具有保护作用.
- 对其他不良妊娠结果观察到负面趋势,需要进一步调查.
- 旨在改善母亲握力强度的干预措施可能会改善怀孕结果,但需要更多的研究.
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