肠道微生物群在严重抑郁症中的潜在作用:一篇综述
Mansoor Khaledi1,2, Fatemeh Sameni1, Abolfazl Gholipour2
1Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran.
Heliyon
|July 19, 2024
概括
肠道微生物群的干扰与抑郁症有关. 用益生菌或其他方法改变肠道细菌可能为改善心理健康提供新的途径.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群和宿主免疫具有复杂的,相互依存的关系.
- 肠道细菌社区障碍与降低的代谢物和行为变化有关,包括抑郁症.
- 特定的细菌系如 Bacteroides,Clostridium,Coprococcus,Dialister和Oscillibacter 显示在抑郁症中的丰度发生变化.
研究的目的:
- 审查有关肠道微生物群失调和抑郁症之间的联系的当前研究.
- 探索肠道微生物群的变化如何影响心理健康和抑郁症状.
主要方法:
- 审查关于肠道微生物群和抑郁症的现有科学文献.
- 对调查压力对肠道细菌组成的影响的研究分析.
- 检查微生物代谢物和免疫相互作用在抑郁症中的作用.
主要成果:
- 暴露于压力会改变关键肠道细菌的相对丰度,一些减少反映了抑郁症患者的情况.
- 肠道微生物群影响天生的免疫力,并产生影响中枢神经系统 (CNS) 的代谢物 (神经递质,SCFA).
- 特定的益生菌 (例如,Bifidobacterium longum NCC3001,Clostridium butyricum CBM588,Lactobacillus acidophilus) 显示出抗抑郁作用.
结论:
- 由代谢物和免疫信号的变化所表现的肠道失调症,可以导致抑郁症.
- 通过诸如益生菌,益生菌和便微生物种移植等干预措施调节肠道微生物群,有望改善抑郁症状.
- 对宿主-大脑-微生物群轴的进一步研究可能会导致针对精神健康障碍的新型治疗策略.
相关概念视频
Depression: Overview
231
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
231
Irritable Bowel Syndrome I: Introduction
264
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
264
Antidepressant Drugs: MAOIs and Other Agents
209
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
209
Bacterial Flora of the Large Intestine
414
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
414
Depressive Disorders: MDD and Dysthymia
90
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
90
Anatomy of the Intestines
71.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.7K


