可生物降解材料的进步:骨科应用的降解机制,机械性能和生物相容性
Muzamil Hussain1, Shahzad Maqsood Khan1, Muhammad Shafiq1
1Institute of Polymer & Textile Engineering, University of the Punjab, Lahore, 54000, Pakistan.
Heliyon
|July 19, 2024
概括
基于 (Mg) 和 (Zn) 的生物降解材料由于其理想的降解和机械配置,对治疗骨病有很大的希望. 本综述详细介绍了它们的特性,制造和生物相容性,重点介绍了体内试验.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科工程 整形外科工程
- 材料科学 材料科学 材料科学
背景情况:
- 基于Mg和基于Zn的可生物降解材料为下一代骨科植入物提供了潜力.
- 这些材料具有理想的降解和机械性能,适用于骨缺陷修复.
研究的目的:
- 审查用于骨应用的基于Mg和基于Zn的生物降解材料的现状.
- 讨论关键性质,制造影响,降解机制和生物相容性测试.
主要方法:
- 基于Mg和Zn的可生物降解材料的文献综述.
- 分析影响材料性能的因素:制造,微观结构,合金和后加工.
- 讨论降解途径 (溶解,氧化) 和细胞相互作用.
- 通过体外和体外研究评估生物相容性.
主要成果:
- 基于Mg和Zn的材料表现出可调节的降解和机械性能.
- 制造技术,微观结构,合金元素和后处理对材料性能产生重大影响.
- 降解通过溶解和氧化发生,受生物环境的影响.
- 在体外生物相容性测试至关重要,与体外细胞系研究相比,它提供了更好的洞察力.
结论:
- 基于Mg和基于Zn的可生物降解材料是骨再生的有希望的候选材料.
- 通过可控的制造和组成优化材料特性是关键.
- 进行彻底的体内评估至关重要,以确认临床转换的安全性和有效性.
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