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囊性纤维化患者的状况;系统性审查和元分析

Mahsa Malekahmadi¹, Sepideh Soltani², Naseh Pahlavani^3,4

¹Imam Khomaini hospital complex, Tehran University of Medical Sciences, Tehran, Iran.

|July 19, 2024

概括

囊性纤维化患者血液中含量较低,与健康人群相比. 这项研究回顾了囊性纤维化症中状况和补充试验,突出了需要更多研究的需要.

科学领域:

医学研究医学研究
营养科学营养科学
遗传学遗传学是一个

背景情况:

囊性纤维化 (CF) 是一种遗传性疾病,影响肺部和消化,往往导致缺乏.
患有CF的患者面临着影响多个器官系统的缩分泌物的挑战.
了解状况对于管理CF相关并发症至关重要.

研究的目的:

与健康对照人群相比,研究囊性纤维化患者的水平.
对CF中补充剂的现有临床试验进行审查.
评估状况和CF之间的关联.

主要方法:

在主要数据库 (Web of Science,Scopus,PubMed/Medline,Cochrane) 进行了系统的文献搜索,截至2023年12月.
使用随机效应模型进行元分析,以计算聚合加权平均差异 (WMD) 和置信区间 (CI).
根据地区,样本类型,测量方法,补充剂和年龄进行了子组分析.

主要成果:

对9项研究 (383名参与者) 的分析表明,CF患者儿童和青少年的含量与对照人群相比显著降低 (WMD = -11.97μg/dL).
对8项研究 (320名参与者) 的分析证实了CF患者血清和血含量较低 (WMD = -14.31 μg/dL).
相反,CF患者的唾液和唾液中发现含量显著更高.

结论:

囊性纤维化患者在循环系统中表现出降低的水平.
补充剂可能会缓解CF的呼吸道和胃肠道症状.
需要进一步严格的临床试验来验证在CF治疗中的治疗作用.

关键词:

青少年是一个青少年.成年人成年人成年人成年人成年人成年人孩子孩子孩子孩子囊性纤维化症是什么微量元素的微量元素是什么缺是因为缺乏.的地位的地位

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