微聚合物相关塑化剂对内分泌干扰的有害影响
Utsa Saha1, Puja Kumari2,3, Aishee Ghosh1
1KIIT School of Biotechnology, KIIT University, Bhubaneswar, 751024, Odisha, India.
Materials today. Bio
|July 19, 2024
概括
微聚合物 (MP) 和纳米聚合物 (NP),以及增塑剂,破坏激素功能和代谢过程. 本综述探讨了它们的来源,分布和对人类健康和环境的内分泌干扰影响.
科学领域:
- 环境科学 环境科学
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 广泛使用聚合物对人类健康和生态系统构成风险.
- 微聚合物 (MP) 和纳米聚合物 (NP) 越来越多地被认为对器官系统有不利影响.
- 塑化剂,常见的聚合物添加剂,被确定为内分泌干扰化学品 (EDC).
研究的目的:
- 审查MP,NP和相关塑化剂作为EDC的来源,分布和影响.
- 阐明MP,NP和塑化剂破坏内分泌功能的机制.
- 突出这些污染物对荷尔蒙路径和恒温的影响.
主要方法:
- 关于聚合物,增塑剂和内分泌干扰的科学研究的综合文献综述.
- 对国会议员和国民议员的来源和环境分布的数据进行分析.
- 检查详细研究这些物质对内分泌腺体的分子和生理影响的研究.
主要成果:
- 议员,NP和塑化剂干扰关键的内分泌腺体:垂体,甲状腺,上腺和生殖腺.
- 这些污染物干扰激素信号通路,这些通路对于恒常,生育和发育至关重要.
- 有证据表明,它对代谢过程,神经发育和胎儿生长有重大影响.
结论:
- 国会议员,NP和塑化剂对内分泌系统的完整性构成重大威胁.
- 了解它们的内分泌干扰机制对于减轻健康和环境风险至关重要.
- 需要进一步的研究,以充分评估和解决与聚合物相关的EDCs的普遍影响.
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