关于COVID-19流行病的前三波风险因素,初始诊所人口概况,严重程度和结果的比较研究
Indranil Thakur1, Arabinda Chatterjee2, Ashis Kumar Ghosh3
1General Medicine, DHGMCH, Diamond Harbour, West Bengal, India.
Journal of family medicine and primary care
|July 19, 2024
概括
COVID-19的第二波是最严重的,临床得分和死亡率更高. 患有并发症的患者的结果较差,特别是在第一波疫情期间.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在2020年3月至2022年12月期间,SARS-CoV-2大流行病发生在三个不同的波浪中.
- 这项研究检查了农村三级医院在这些波浪期间成年非产科COVID-19患者的临床参数.
研究的目的:
- 为了比较COVID-19患者的临床参数和结果,跨越三个大流行浪潮.
- 为了确定影响不同SARS-CoV-2激增期间严重程度和死亡率的因素.
主要方法:
- 对第一波,第二波和第三波期间分别入院的272名,853名和97名患者的回顾性分析.
- 收集的数据包括临床,流行病学和实验室参数,以及修改紧急警告得分 (m-EWS) 和快速序列器官衰竭评估 (qSOFA) 得分.
- 进行了统计分析,以比较波和患者组之间的结果.
主要成果:
- 第二波显示了统计学上显著更高的m-EWS和qSOFA分数.
- 虽然第二波的死亡率最高 (14.89%),但这一差异在不同波的死亡率上并没有统计学意义.
- 第一个浪潮记录了最长的住院时间 (平均=9.99天).
- 患有并发症和没有并发症的患者之间的死亡率差异在整体和第1波中显著,但在第2波或第3波中没有显著.
结论:
- 第二次COVID-19浪潮是最严重的,其特点是临床严重性得分更高.
- 较差的患者结局与并发症有关,特别是在第一波大流行期间.
相关概念视频
01:18Steps in Outbreak Investigation
121
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
121
01:18Factors Affecting Illness
4.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.2K
01:20Comparing the Survival Analysis of Two or More Groups
172
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
172
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
125
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
125
01:26Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
01:20COPD: Pathogenesis and Clinical Features
252
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
252