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Classification of Leukocytes01:30

Classification of Leukocytes

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Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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相关实验视频

Updated: Jun 20, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
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颗粒细胞瘤最初伪装成细胞炎

Ori Berger1, Ofer Arnon1, Bernardo A Lomeli1

  • 1From Plastic Surgery Department, Barzilai University Hospital Medical Center, Ashkelon, Israel.

Plastic and reconstructive surgery. Global open
|July 19, 2024
PubMed
概括
此摘要是机器生成的。

颗粒细胞瘤 (GCTs) 是一种罕见的 Schwann 细胞生长. 这个案例突出了模仿细胞炎的GCT,强调组织学,以准确诊断和治疗不寻常的表现.

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科学领域:

  • 在瘤学瘤学.
  • 皮肤病理学 皮肤病理学
  • 手术病理学手术病理学

背景情况:

  • 颗粒细胞瘤 (GCTs) 是源自斯万细胞的不常见瘤.
  • 它们通常呈现为皮肤和软组织的良性病变.
  • 非典型的表现可能会带来诊断挑战.

研究的目的:

  • 报告一种罕见的颗粒细胞瘤病例,呈现为脚上的纤维炎.
  • 强调在异常软组织病变的差异诊断中考虑GCT的重要性.
  • 突出组织学检查在确认GCT诊断中的关键作用.

主要方法:

  • 一个患有足部病变的患者的临床表现审查.
  • 切除的组织的组织病理学检查.
  • 手术切除和重建的规划.

主要成果:

  • 这种最初被误诊为细胞炎的病变在组织学上被证实是颗粒细胞瘤.
  • 在诊断后进行了成功的外科切除和重建.
  • 该病例证明了GCT的非典型呈现.

结论:

  • 颗粒细胞瘤可以异常呈现,模仿诸如细胞炎等常见疾病.
  • 组织学评估对于精确诊断颗粒细胞瘤至关重要.
  • 早期和准确的诊断有助于适当的管理,并改善患者的治疗结果.